Elevated plasma factor VIII in a mouse model of low-density lipoprotein
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متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor–related protein deficiency
It has been established that low-density lipoprotein receptor-related protein (LRP) is involved in the cellular uptake and degradation of coagulation factor VIII (FVIII) in vitro. To address the physiologic role of LRP in regulating plasma FVIII in vivo, we used cre/loxP–mediated conditional LRPdeficient mice (MX1cre LRPflox/flox). Upon inactivation of the LRP gene, MX1cre LRPflox/flox mice had...
متن کاملElevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.
It has been established that low-density lipoprotein receptor-related protein (LRP) is involved in the cellular uptake and degradation of coagulation factor VIII (FVIII) in vitro. To address the physiologic role of LRP in regulating plasma FVIII in vivo, we used cre/loxP-mediated conditional LRP- deficient mice (MX1cre(+)LRP(flox/flox)). Upon inactivation of the LRP gene, MX1cre(+)LRP(flox/flox...
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متن کاملInvolvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice.
Factor VIII is tightly noncovalently linked to von Willebrand factor (vWF) in plasma with a stoichiometry of 1:50, and vWF deficiency results in secondary factor VIII deficiency, with accelerated clearance of factor VIII from the circulation. We used a murine model of severe von Willebrand disease (vWF knockout mice) to study the effect of a recombinant vWF/pro-vWF preparation (rpvWF) on factor...
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